Upjohn share the same NDA. As long as glyburide holds a BX rating, substitution of products of different NDAs is not permissible without the physician's permission. The United States pharmacopeia. The national formulary. USP 23rd revision January 1, 1995. NF 18th ed January 1, 1995. Rockville, MD: The United States Pharmacopeial Convention, Inc; 1995 First supplement, 1995. p. 2465-6. The dose of these medicines will be different for different patients. boots pharmacy zestril cost
The doctors have prescribed 5mg Glipizide Glucotrol in addition to my regular dose of 750mg of Metformin twice daily. I have been taking this cocktail for about 4 days now, and my blood glucose levels have dropped to below 150. I've also eliminated all external sugars from my diet - no fruit juices, no sweet dairy products etc - and am exercising for 30 minutes each day. I am restricting my diet to less than 250 carbs per day. Clinical chemistry, toxicology, serology. In: Wyngaarden JB, Smith LH. Cecil textbook of medicine. 18th ed. Philadelphia: Saunders; 1988. p. 2397. Passa PH, Marre M, Leblanc H. Enalapril, captopril and blood glucose. Lancet 1986 Jun 21; 18495: 1447.
Lebovitz HE. Glipizide: a second-generation sulfonylurea hypoglycemic agent. Pharmacotherapy 1985; 5: 63-7. Oral, initially 100 to 125 mg once a day, the dosage being increased by 50 to 125 mg at three- to five-day intervals as needed. Feeley J, Peden N. Enhancement of sulphonylurea-induced hypoglycaemia with cimetidine. Br J Clin Pharmacol 183; 15: 607.
Beyer WF, Jensen EH. Tolbutamide. In: Florey K, editor. Analytical profiles of drug substances. New York: Academic Press, 1974; 3: 513-43. Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines, such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. During conversion from insulin therapy to tolazamide therapy, no gradual dosage adjustment usually is required for patients using less than 40 USP Units of insulin daily. Patients requiring 40 or more USP Units daily should receive a 50% reduction of insulin during the first few days, with gradual dosage adjustment of tolazamide as needed. Hospitalization for some patients on a higher insulin dosage may be required for uneventful conversion.
Rizza RA, Cryer PE, Gerich JE. Role of glucagon, catecholamines and growth hormone in human glucose counterregulation. J Clin Invest 1979 Jul; 64: 62-71. Rapidly and well absorbed but may have wide inter- and intra-individual variability. Beta-adrenergic blocking agents, including ophthalmics, if significant absorption occurs beta-adrenergic blocking agents may decrease the hypoglycemic effects of sulfonylureas to some extent by inhibition of insulin secretion, modification of carbohydrate metabolism, and increased peripheral insulin resistance, leading to hyperglycemia; an adjustment in dose may be required. Ferner RE, Chaplin S. The relationship between the pharmacokinetics and the pharmacodynamic effects of oral hypoglycaemic drugs. Clin Pharmacokinet 1987 12: 379-401. Halter JB, Morrow LA. Use of sulfonylurea drugs in the elderly patients. Diabetes Care 1990 Feb; 13 Suppl 2: 86-92. This information is generalized and not intended as specific medical advice. Van Praag HM, Leijnse B. The influence of some antidepressives of the hydrazine type on the glucose metabolism in depressed patients. Clin Chim Acta 1963; 8: 466-75. Dolger H. Experience with the tolbutamide treatment of 500 cases of diabetes on an ambulatory basis. Ann NY Acad Sci 1957; 711: 275-9. Food delays absorption of gliclazide up to 187 minutes; may be best taken 30 minutes before or with a meal. Beta-adrenergic blocking agents may increase the chance that high or low blood sugar can occur. Also, they can hide symptoms of low blood sugar such as fast heartbeat. Niemi M, Kivisto KT, Backman JT, Neuvonen PJ. Effect of rifampicin on the pharmacokinetics and pharmacodynamics of glimepiride. Glyburide DiaBeta, Hoechst Marion Roussel. In: PDR Physicians' desk reference. 52nd ed. 1998. Montvale, NJ: Medical Economics Company; 1998. p. 1217-9. Cipro ciprofloxacin hydrochloride US prescribing information. Goldner MG, Zarowitz H, Akgun S. Hyperglycaemia and glycosuria due to thiazide derivatives administered in diabetes mellitus. N Engl J Med 1960; 2628: 403-5.
USP DI Volume III, Approved drug products and legal requirements. 18th ed. Rockville, MD: The United States Pharmacopeial Convention, Inc; 1998. Br J Clin Pharmacol 1986; 22: 43-8. Increasing your dose when you plan to eat an unusually large dinner, such as on holidays. This type of increase is called an anticipatory dose. Managing with potassium supplements. Tolbutamide interferes with thyroidal uptake of I 123 and I 131. Chlorpropamide Diabinese, Pfizer. In: Krogh CME, editor. CPS Compendium of pharmaceuticals and specialties. 29th ed. Ottawa: Canadian Pharmaceutical Association; 1994. p. 362-3. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Acetohexamide has been shown to be teratogenic in animal studies when large doses were administered. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Williams G. Management of non-insulin-dependent diabetes mellitus. Lancet 1994 Jan; 343: 95-100. There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. Immediately treating with 50 mL of 50% dextrose injection given intravenously to stabilize the patient. amantadine
Toivonen S, Mustala O. Diabetogenic action of frusemide. BMJ 1966; 1: 920-1. Simpson HCR, Sturley R, Stirling CA, et al. Combination of insulin with glipizide increases peripheral glucose disposal in secondary failure type 2 diabetic patients. Diabet Med 1989; 72: 143-7. Attempts should be made to identify the minimum effective dose of each drug. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Lardinois, CK, Liu GC, Reaven GM. Glyburide in non-insulin-dependent diabetes: Its therapeutic effect in patients with disease poorly controlled by insulin alone. Arch Intern Med 1985; 145: 1028-32. Maintenance: Oral, 80 to 320 mg a day with meals. Safety and efficacy have not been established. Noroxin norfloxacin US prescribing information. Continue taking your sulfonylurea and try to stay on your regular meal plan. If you have trouble eating solid food, drink fruit juices, nondiet soft drinks, or clear soups, or eat small amounts of bland foods. A dietitian or your health care professional can give you a list of foods and the amounts to use for sick days. If you have been smoking for a long time and suddenly stop, your dosage of sulfonylurea may need to be reduced. If you decide to quit, tell your doctor first. Glyburide Albert Glyburide, Albert Pharma. In: Gillis MC, editor. CPS Compendium of pharmaceuticals and specialties. 33rd ed. Ottawa: Canadian Pharmacists Association; 1998. p. 43-4. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. how to order dilantin pills dilantin
Lower initial dose may be required. Use this medicine only as directed even if you feel well and do not notice any signs of high blood sugar. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Ikeda T, Fujiyama K, Hoshino T, et al. Glucose tolerance and gastric emptying in thyrotoxic rats. Metabolism 1989 Sep; 389: 874-7. Palmer KJ, Brogden RN. Gliclazide: an update of its pharmacological properties and therapeutic efficacy in non-insulin-dependent diabetes mellitus. Drugs 1993; 461: 92-125. Jackson RA. Mechanisms of age-related glucose intolerance. Diabetes Care 1990 Feb; 13 Suppl 2: 9-19. Initial: Oral, 160 mg two times a day with meals. Studies in female rats and the first generation offspring of treated male and female rats showed no evidence of impaired fertility. It occurs more often with long-acting sulfonylureas, such as chlorpropamide or glyburide, when other predisposing factors or conditions are present, and can be relapsing and prolonged; glyburide results in a higher fatality rate than does chlorpropamide. Seltzer HS. Drug-induced hypoglycemia: a review based on 473 cases. Diabetes 1972; 21: 955-66. Tell your doctor if your condition does not improve or if it worsens your are too high or too low. Studies in humans have not been done. Gliclazide is not recommended for use during pregnancy. Niemi M, Backman JT, Neuvonen M, Neuvonen PJ, Kivisto KT. Rifampin decreases the plasma concentrations and effects of repaglinide. The type of diabetes treated with this medicine is rare in children. However, if a child needs this medicine, the dose would have to be determined by the doctor. Studies in male and female rats given 75 times the maximum human dose showed no evidence of impaired fertility. brand name of luvox cough syrup
Also, using ERCP, that have passed outside the gallbladder and into the bile duct can often be removed. Is Endoscopy Safe? F in a well-closed container, unless otherwise specified by manufacturer. The United States pharmacopeia. The national formulary. USP 23rd revision January 1, 1995. NF 18th ed January 1, 1995. Rockville, MD: The United States Pharmacopeial Convention, Inc; 1995. p. 357, 1565. Pugh JA, Wagner ML, Sawyer J, et al. Is combination sulfonylurea and insulin therapy useful in NIDDM patients? Different people may feel different symptoms of low blood sugar. Moderate. These medicines may cause some risk when taken together. Klein W. Sulfonylurea-metformin-combination versus sulfonylurea-insulin-combination in secondary failures of sulfonylurea monotherapy. Results of a prospective randomized study in 50 patients. Diabete Metab 1991 May; 17 1 Pt 2: 235-40. Your doctor may want you to check your blood sugar more often while taking your antibiotic. If you experience a sudden onset of chills, cold sweat, blurred vision, dizziness, drowsiness, shaking, rapid heart rate, weakness, headache, fainting, tingling of the hands or feet, or hunger, check your blood sugar if possible and treat yourself for low blood sugar by eating a quick source of glucose such as glucose tablets or gel, table sugar, honey, candy, orange juice, or non-diet soda. Stop using your antibiotic and contact your doctor right away. McMurty RJ. Propranolol, hypoglycemia, and hypertensive crisis. Ann Intern Med 1974; 80: 669-70. If high blood sugar is not treated, severe hyperglycemia can occur, leading to ketoacidosis diabetic coma and death. Initial: Oral, 1 to 2 mg once a day with breakfast or the first main meal. Archambeaud-Mouveroux F, Nouaille Y, Nadalon S, et al. Interaction between gliclazide and cimetidine. Eur J Clin Pharmacol 1987; 315: 631. Symptoms of severe high blood sugar called ketoacidosis or diabetic coma that need immediate hospitalization include: flushed dry skin, fruit-like breath odor, ketones in urine, passing out, troubled breathing rapid and deep. urim.info zanaflex
Ferrari C, Frezzati S, Testori GP, et al. Potentiation of hypoglycaemic response to intravenous tolbutamide by clofibrate. N Engl J Med 1976 May 20; 29421: 1184. Danazol Sanofi Winthrop. In: PDR Physicians' desk reference. 48th ed. 1994. Montvale, NJ: Medical Economics Data Production Company; 1994. p. 2092-3. Studies in rats and rabbits given 500 times the human dose have not shown evidence of impaired fertility. Swallow tablet whole. Do not break, crush, or chew. Glucose administration is the basis for treatment of hypoglycemia; however, an exposure to sudden or excessive hyperglycemia caused by an injection of hypertonic glucose solution may further stimulate the sulfonylurea-primed pancreas to release more insulin, worsening the hypoglycemia. Take this medication on an empty stomach, 30 minutes before meals. Self TH, Morris T. Interaction of rifampin and chlorpropamide. Dukes MNG, editor. Meyler's side effects of drugs. An encyclopedia of adverse reactions and interactons. 11th ed. Amsterdam: Elsevier; 1988. p. 893-9. Galloway JA, McMahon RE, Culp HW, et al. Metabolism, blood levels and rate of excretion of acetohexamide in human subjects. Diabetes 1967; 162: 118-27.
Protective activity for some cardiac arrhythmias; also, reduces platelet adhesiveness and aggregation and has fibrinolytic activity. Know what to do if symptoms of low blood sugar occur. Eating some form of quick-acting sugar when symptoms of low blood sugar first appear will usually prevent them from getting worse. Acetohexamide and its more potent major metabolite, hydroxyhexamide, have uricosuric properties. Gliclazide, at therapeutic doses, reduces platelet adhesiveness and aggregation by inhibiting arachidonic acid release and thromboxane synthesis, and increasing production of prostacyclin PGI 2 and release of plasminogen activator, which increases fibrinolysis. It is also thought that gliclazide and glyburide have protective activity against cardiac arrhythmias because they can stabilize potassium and calcium concentrations by inhibition of the sodium-potassium-ATPase pump transport system. Tolbutamide and chlorpropamide decrease free water clearance while glyburide, glipizide, and tolazamide produce a mild diuresis effect by enhancement of renal free water clearance. In contrast to glyburide, tolazamide and tolbutamide increase hexose uptake in adipocytes and myocytes. Sulfonylureas directly increase the secretion of pancreatic and gastric somatostatin and do not seem to have a direct effect on glucagon. Displacement from plasma proteins by other medications is less likely than with ionic sulfonylureas. Marchetti P, Navalesi R. Pharmacokinetic-pharmacodynamic relationships of oral hypoglycaemic agents. Clin Pharmacokinet 1991; 16: 100-28. Gram J, Kold A, Jespersen J. Rise of plasma t-PA fibrinolytic activity in a group of maturity onset diabetic patients shifted from a first generation tolbutamide to a second generation sulphonylurea gliclazide. J Intern Med 1989; 2254: 241-7. Seltzer HS. Drug-induced hypoglycemia: a review based on 1418 cases. Endocrinol Metab Clin North Am 1989 Mar; 181: 163-81. Morley JE, Perry HM. The management of diabetes mellitus in older individuals. Drugs 1991; 414: 548-65. Ferriere M, Lachkar H, Richard JL, et al. Captopril and insulin sensitivity. Ann Intern Med 1985; 102: 134-5. The daily number of calories in the meal plan should be adjusted by your doctor or a registered dietitian to help you reach and maintain a healthy body weight. In addition, regular meals and snacks are arranged to meet the energy needs of your body at different times of the day. Lewis-Hall F. Dear Healthcare Provider letter. Koda-Kimble MA, Young LY, editors. Applied therapeutics: the clinical use of drugs. 5th ed. Vancouver, WA: Applied Therapeutics, Inc; 1992. Avoid too much sun. Maintenance: Oral, 250 to 1000 mg once a day before breakfast or 1000 to 1500 mg divided into two doses taken before breakfast and evening meals. Not recommended for use in patients with renal function impairment. crixivan
Maintenance: Oral, 1 to 4 mg once a day. After reaching a dose of 2 mg, increases in dosage should be made in increments of up to 2 mg every one to two weeks based on blood glucose response. Studies in rats given doses of tolbutamide that were 25 to 100 times greater than the human dose have shown teratogenic effects, such as ocular and bone abnormalities, and increased mortality in the offspring. Repeat studies in rabbits showed no teratogenic effects. Rifabutin Mycobutin, Adria. In: PDR Physicians' desk reference. 48th ed. 1994. Montvale, NJ: Medical Economics Data Production Company; 1994. p. 463-5. Del Prato S, Vigili de Kreutzenberg S, Riccio A, et al. Partial recovery of insulin secretion and action after combined insulin-sulfonylurea treatment in Type 2 non-insulin-dependent diabetic patients with secondary failure to oral agents. Diabetologia 1990; 3311: 688-95. When patients are transferred to glyburide from another sulfonylurea antidiabetic medication with the exception of chlorpropamide no transition period is required. When transferring patients from chlorpropamide, caution should be exercised during the first 1 to 2 weeks because of the prolonged retention of chlorpropamide in the body and subsequent overlapping of drug effects that could cause hypoglycemia. purchase vytorin store canada
Studies in rats given 10 times the human dose have shown tolazamide to cause reduced litter sizes. No teratogenic effects were found. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Oral, 100 to 250 mg as a single dose daily, the dosage being adjusted at two- or three-day intervals as needed and tolerated. Weight gain is greater with combination use of insulin and sulfonylureas than with sulfonylurea therapy alone. Gliclazide alone, or metformin in combination with sulfonylureas, usually results in less weight gain than other sulfonylureas and has exhibited a weight loss effect. Pharmaceutical, Inc. February, 2011. Sylvalahti E, Pihlajamki K, Iisalo E. Effect of tuberculostatic agents on the response of serum growth hormone and immunoreactive insulin to intravenous tolbutamide, and on the half-life of tolbutamide. Int J Clin Pharmacol 1976; 13: 83-9. Not included in Canadian product labeling. MacWalter RS, Debani AH, Feeley J, et al. Potentiation by ranitidine of the hypoglycaemic response to glipizide in diabetic patients. Br J Clin Pharmacol 1985; 21: 121-2. Sulfonylureas can make you more sensitive to the sun. Use of sunblock products that have a skin protection factor SPF of at least 15 on your skin and lips can help to prevent sunburn. Do not use a sunlamp or tanning bed or booth. Connor H, Marks V. Alcohol and diabetes. A position paper prepared by the Nutrition Subcommittee of the British Diabetic Association's Medical Advisory Committe and approved by the Executive Council of the British Diabetic Association. Human Appl Nutr 1985; 39A, 393-9. Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. When patients are transferred to tolazamide from another sulfonylurea antidiabetic medication with the exception of chlorpropamide no transition period is required. When transferring patients from chlorpropamide, caution should be exercised during the first 1 to 2 weeks because of the prolonged retention of chlorpropamide in the body. Sometimes patients with type 2 diabetes might need to change to treatment with insulin for a short period of time during pregnancy or for a serious medical condition, such as diabetic coma; ketoacidosis; severe injury, burn, or infection; or major surgery. In these conditions, insulin and blood sugar can change fast and blood sugar can be best controlled with insulin instead of a sulfonylurea. Jaakkola T, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ. Effect of rifampicin on the pharmacokinetics of pioglitazone. Campbell DB, Lavielle R, Nathan C. The mode of action and clinical pharmacology of gliclazide: a review. Diabetes Res Clin Pract 1991; S21-S36. cheap generic evista next day delivery
During conversion from insulin therapy to glipizide therapy, no gradual dosage adjustment usually is required for patients using less than 20 USP Units of insulin daily. For patients using 20 or more USP Units daily, a 50% reduction of insulin the first day, with gradual dosage adjustments of glipizide as needed, is desirable. Hospitalization for some patients on a higher insulin dosage may be required for uneventful conversion. Johnstone BB. Diabetes mellitus in patients on lithium. Lancet 1977: 935-6. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Occasionally, divided doses are administered, usually twice a day before the morning and evening meals, to improve gastrointestinal tolerance. Do not take other medicines without advice from your doctor. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. De Weille JR. Modulation of ATP sensitive potassium channels. Cardiovasc Res 1992; 26: 1017-20. Other than the above information, there is no additional information relating to its proper use, precautions, or side effects for this use. Your doctor will give you instructions about diet, exercise, how to test your blood sugar levels, and how to adjust your dose when you are sick. Initial: Oral, 1000 to 2000 mg a day as single morning or divided doses. Young DS, editor. Effects of drugs on clinical laboratory tests. 3rd ed. Washington: AACC Press; 1990. Thonnard-Neumann E. Phenothiazines and diabetes in hospitalized women. Am J Psychiat 1968 Jun; 124: 978-82. serophene
This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use and wear protective clothing when outdoors. The intravenous glucose therapy should not be terminated suddenly. A central venous line for long-term use 24 to 48 hours in cases of chlorpropamide overdose may be required. Oral glucose cannot be relied upon to maintain euglycemia because 60% of an oral glucose dose is stored as hepatic glycogen with only 15% left for brain utilization and 15% for insulin-dependent tissues even though 75% of oral glucose is absorbed after 150 to 180 minutes. Groop L, Totterman KJ, Harno K, et al. Influence of beta-blocking drugs on glucose metabolism in patients with non-insulin dependent diabetes. Acta Med Scand 1982; 211: 7-12. Craig J, Abu-Saleh M, Smith B, et al. Diabetes mellitus in patients on lithium. Lancet 1977 Nov 12; 28046: 1028. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Christensen LK, Skovsted L. Inhibition of drug metabolism by chloramphenicol. Lancet 1969; 1397. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. No teratogenic effects were found in studies of mice and rabbits. Embryotoxicity was not seen in studies of rats. However, a significant decrease in offspring viability at 48 hours was seen when pregnant females were treated up to delivery. It is unclear how this relates to the use of gliclazide or if it applies to humans. Jahnchen E, Meinertz T, Gilfrich HJ, et al. Pharmacokinetic analysis of the interaction between dicoumarol and tolbutamide in man. Eur J Clin Pharmacol 1976; 10; 349-56. The amount of your diabetes medicine in your blood may decrease and it may not work as well. Then, your doctor may change your dose a little at a time if needed. The dose is usually not more than 20 mg a day. If your dose is 10 mg or more, the dose usually is divided into two doses. These doses are taken with the morning and evening meals. Zaman R, Kendall MJ, Biggs PI. The effect of acebutalol and propranolol on the hypoglycaemic action of glibenclamide. Br J Clin Pharmacol 1982; 13: 507-12. At first, 250 milligrams mg once a day. Some elderly people may need a lower dose at first. Then, your doctor may change your dose a little at a time if needed. Distributed into breast milk. Amaryl glimepiride US prescribing information.
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Panten U, Schwantecher M, Schwantecher C. Pancreatic and extrapancreatic sulfonylurea receptors. Horm Metab Res 1992; 24: 549-54. Initial: Oral, 250 mg once a day, the dosage being changed by 50 to 125 mg every three to five days if needed. Sometimes insulin that is being produced by the body is not able to help sugar get inside the body's cells. Sulfonylureas help insulin get into the cells where it can work properly to lower blood sugar. In this way, sulfonylureas will help lower blood sugar and help restore the way you use food to make energy. Ellenhorn MJ, Barceloux OG. Medical toxicology: diagnosis and treatment of human poisoning. New York: Elsevier; 1988. p. 440-9, 565, 785. felodipine
Engl J Med 1984; 31012: 746-50. If you don't have these reliable forms of glucose, rapidly raise your by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. This dose should also be used in patients with medical problems that make them more sensitive to the effects of glyburide. If an elderly patient tends toward hypoglycemia during the first twenty-four hours after an initial dose of 250 mg at breakfast, the dose should be reduced or the medication discontinued. escitalopram rx cost
There is an increased chance of hypoglycemia occurring if more than one hypoglycemia-causing agent is used concurrently with sulfonylureas. If the need exists to administer any medications that may affect metabolic or glycemic control of type 2 diabetes, blood glucose concentrations should be monitored by the patient or health care professional. This is particularly important when any medication is added to or removed from an established drug regimen. Subsequent adjustments in diet or antidiabetic agent dosage or both may be necessary; these adjustments may differ depending on the severity of the diabetes.
Chlorpropamide crosses the placenta. Sulfonylureas should not be used during pregnancy, especially when insulin is available. In the rare cases that a sulfonylurea is used, chlorpropamide and glipizide should be discontinued at least 1 month before delivery date and other sulfonylureas stopped at least 2 weeks before delivery date. Studies in humans have not been done. Reynolds, JEF, editor. Martindale: the extra pharmacopeia. 28th ed. London: The Pharmaceutical Press; 1982. Your blood sugar may be increased or decreased, partly because the medicine may be removed from the body too fast or too slow. Until your thyroid condition is controlled, the amount of sulfonylurea you need may change.